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Author Note: I am in no a professional of any kind. I am strongly against self-diagnosis, and encourage my audience to please seek the professional advice of their own trusted medical professional and any other trusted professional depending on the topic at hand. The Abler Blog ONLY PROVIDES LIMITED GENERAL INFORMATION, and ALWAYS CITES WHERE THEY FIND THEIR RESOURCES AND OR INFORMATION.
Jessica Niziolek,
Founder Of The Abler Blog, and online community.
March Monthly Topic: Progressive Supranuclear Palsy (PSP)
Recources Used For Research Purposes Only
National Institute Of Neurological Disorders And Stroke & Medline.org
What Is PSP(progressive supranuclear palsy?)
It is a rare neurological disorder.
What Does It Effect?
PSP effects the body’s movements, balance, the ability to walk, and the person’s eye movements.
What Causes PSP?
It is caused by effecting the nerves in that the brain that specifically control the body’s movements, and thinking. It also one of several neurological disorders that fall under what’s known as: atypical Parkinsonism.
What Is atypical Parkinsonism?
They are progressive disease that show some signs of Parkinson’s, but do not respond well to treatments with levodopa. It is also associated an abnormal build up for protein in the brain.
What Is Levodopa?
It is a medication used to treat symptoms of Parkinson’s and Parkinson’s like symptoms that occur when the brain shows swelling. Or injury to the brain’s nervous system, that can be caused by carbon monoxide poisoning or manganese poisoning.
How is PSP Different From Parkinson’s?
While there are some symptoms that are similar to Parkinson’s, symptoms of PSP start when a person’s is in their late 60’s later years that a person(s) who has a diagnosis of Parkinson’s. Symptoms of PSP generally worsen at a faster pace, and the person can develop severe disability within a three-to five year span rein the onset os show symptoms. For further explanation, of the differences between these two conditions please visit this link: https://www.ninds.nih.gov/health-information/disorders/progressive-supranuclear-palsy-psp
What Are Some Symptoms Of PSP?
: Difficulty moving their body
: Walking/Balance
: Swallowing/Slurred speech
: Can cause serious complications such has the person developing pneumonia.
Who is More Likely To Be Diagnosed With PSP?
While there is known cause for what causes this condition, it’s suggested that this condition hits certain parts of the brain, using progressive damage. The main area being the person’s brain stem. One of the areas causing the death of the person’s brain’s cells is an area called, the substantia nigra, This area not only plays a part in effecting the person’s motor skills, but this area also is a common factor for people who have Parkinson’s Disease.
What is The tau protein?
It is a protein that stabilizes the nerve cells in the brain. (the neurons) in the brain. And when PSP appears with a goal is to destroy the health brain cells. Effecting the brains to function at a healthy level as it did before diagnosis.
While PSP usually shows up sporadically and at times randomly and without a known cause. On a rare occasion, PSP can be the result of the MAPT Gene.
What is The MAPT Gene?
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type.
Please Note: That as of right now, for most people with this condition, there is no known genetic link to this condition.
Some Theories For PSP Are
Random genetic changes that occur in particular cells or genes in a specific combination that injures these cells.
Exposure to some unknown environmental factor (such as chemicals in food, air, or water), which slowly damages certain vulnerable areas of the brain.
Cellular damage caused by free radicals, which are reactive molecules produced continuously by all cells during normal metabolism. Although the body has built-in ways to clear free radicals from the body, scientists suspect that—under certain circumstances—free radicals can react with and damage other molecules.
How To Diagnose PSP
As if right now there is no test or imagery that can help with the specific diagnosis of PSP.
It’s suggest that you have your primary doctor help you find the proper diagnosis with a proper exam, both physically and on the neurological side.
How To Treat PSP
There is currently no no treatment to slow and or stop this condition for occurring in someone. Medications seem to have no effect on this condition either.
Parkinson's disease medications rarely help people with PSP. In some individuals, levodopa can treat the slowness, stiffness, and balance problems associated with PSP, but the effect is usually minimal and short-lasting.
Injections of botulinum toxin into muscles around the eyes can help with PSP-associated eye closing.
Some antidepressant drugs may offer some benefits beyond treating depression, such as pain relief and decreasing drooling.
There are also non-drug treatment options for PSP symptoms.
Weighted walking aids can reduce the risk of falling backward.
Bifocals or special glasses called prisms can help reduce difficulty looking down.
Exercise and physical activity (supervised by a healthcare professional) can keep joints limber.
People who have significant trouble swallowing and are at risk of serious choking may have a surgical procedure to place a tube into the stomach to allow the person to get nutrients without having to chew and swallow.
Deep brain stimulation via devices that deliver electrical stimulation to parts of the brain and other surgical procedures commonly used in Parkinson's have not proven effective in PSP.
If you would like to stay update on future updates on this condition, and or find out how you help yourself and or a loved one living with this condition. Please Visit NIH.
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